Because it usually doesn't cause problems, it's rarely diagnosed, making it hard for scientists to say how prevalent the phenomenon truly is. Most of the time, chimerism doesn't manifest itself in any easily observed way. While a similar effect can happen during a blood transfusion, new blood cells are permanent with a bone marrow transplant. Then the marrow, which has stem cells that create red blood cells, circulates, resulting in two sets of DNA in one body. When a mother has a bone marrow transplant, which they may have to treat leukemia or other diseases, her own marrow is destroyed and replaced with a donor's. Researchers aren't sure how prevalent chimerism is: While it was once thought to be extremely rare, scientists are now estimating it’s more common than people realize. Fortunately, doctors eventually determined that she had a second set of DNA that matched. In real life, the most well-known case involving chimerism is probably that of Lydia Fairchild, who nearly lost custody of her children when DNA testing "proved" she wasn't related to them.
#Chimera meaning tv
It may seem like the stuff of science fiction, or at the least, high drama – and, in fact, the phenomenon has been featured in TV shows like House, Law & Order, and Grey's Anatomy.
(It's worth noting that real-life human chimeras do not look like supernatural beings.) The word comes from the mythical Chimera, a creature in Greek mythology that's part lioness, part goat, and part snake. (Gulliver's Travels into several remote nations of the world, by Jonathan Swift)Īs I groped out the door, and knocked at it hesitatingly, I felt that last idea to be a mere chimera.A person who has more than one set of DNA (the genetic material in our bodies) is a chimera, and the condition is called chimerism. These unhappy people were proposing schemes for persuading monarchs to choose favourites upon the score of their wisdom, capacity, and virtue of teaching ministers to consult the public good of rewarding merit, great abilities, eminent services of instructing princes to know their true interest, by placing it on the same foundation with that of their people of choosing for employments persons qualified to exercise them, with many other wild, impossible chimeras, that never entered before into the heart of man to conceive and confirmed in me the old observation, that there is nothing so extravagant and irrational, which some philosophers have not maintained for truth. (Melanoma TRP2 CTL Epitope Vaccine SCIB1, NCI Thesaurus) (Frankenstein, by Mary Wollstonecraft Shelley)Ī proprietary DNA-based cancer vaccine that encodes a melanoma antigen tyrosinase-related protein 2 (TRP2) cytotoxic T-lymphocyte (CTL) epitope and a modified monoclonal antibody, a chimera of human IgG1/murine IgG2a with T cell mimotopes expressed within the complementarity-determining regions (CDR) of the antibodies, with potential immunostimulating and antineoplastic activities.
I was required to exchange chimeras of boundless grandeur for realities of little worth. There have been eccentric inventors, starving their families while they sought such chimeras as perpetual motion. (Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic T Lymphocytes GRm13Z40-2, NCI Thesaurus) The IL13-zetakine consists of an extracellular IL-13 E13Y mutein-human IgG4 hinge-Fc chimera fused to human cytoplasmic CD3-zeta via the transmembrane domain of human CD4. (Multicopy Single-stranded DNA, NCI Thesaurus)ĭuring the intervening period I had no time to nurse chimeras and I believe I was as active and gay as anybody-Adele excepted. (AU RNA Binding Protein, NCI Thesaurus/LocusLink)Ī partial congenic mouse with background strain of C57BL/6 and 129/Sv chimera, containing a heterozygous or homozygous p53 mutation.Ī DNA/RNA chimera comprised of a single-stranded DNA molecule covalently bound to an internal guanosine of a RNA molecule. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity.
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